الرئيسية التحكم التسجيل
 

 
 
العودة   منتديات الكيمياء الحيوية للجميع > الاقسام الاكاديمية > قسم الاسئله و الاستفسارات - Questions
 
 

قسم الاسئله و الاستفسارات - Questions هنا تطرح اسئلتكم و استفساراتكم للاجابة عليها

إضافة رد
 
 
 
أدوات الموضوع انواع عرض الموضوع
 
 
 
 
قديم 08-19-2008, 12:53 AM   #1
نورا
بيوكيميائي برونزي
 
الصورة الرمزية نورا

 









نورا غير متواجد حالياً
افتراضي ما هو تحليل A.s.m.A

ما هو تحليل A.s.m.A

اللى يعرف بالله عليكوا يرد عليا
جزاكم الله خيرا2الله2الله



من مواضيع نورا في المنتدى

التوقيع

   
رد مع اقتباس
 
 
 
 
قديم 08-19-2008, 04:34 AM   #2
الريمـ
ملك الكيمياء الحيوية للجميع
 
الصورة الرمزية الريمـ

 









الريمـ غير متواجد حالياً
افتراضي

من حظك اني هينا 1هه

شوفي هالمقطع يمكن يفيدك

ASMA
Also known as: Smooth Muscle Antibody (SMA), F-Actin Antibody
Formal name: Anti-Smooth Muscle Antibody and Anti-Actin Antibody
Why get tested?
To help diagnose autoimmune hepatitis and distinguish it from other causes of liver injury

When to get tested?
When a patient has hepatitis that the doctor suspects may be due to an autoimmune-related process


What is being tested?
This test measures the amount of anti-smooth muscle antibodies (ASMA) in the blood. ASMA are proteins produced by the body’s immune system to work against its own cytoskeletal proteins. The production of ASMA is strongly associated with chronic autoimmune hepatitis but may also be seen in other forms of liver disease and with other autoimmune disorders such as primary biliary cirrhosis. Autoimmune hepatitis presents as an acute or chronic inflammation of the liver that is not caused by another discernable cause (such as a viral infection, drug, toxin, hereditary disorder, or alcohol abuse). It can lead to cirrhosis (liver damage and scarring) and, in some cases, to liver failure.
Autoimmune hepatitis can be found in anyone at any age, but about 80% of those affected are women. In the United States, more than 80% of patients with this disorder will have ASMA, either alone or along with ANA (antinuclear antibodies). Anti-actin is an antibody targeted at actin, a specific cytoskeletal protein. Some recent studies suggest that it is a more specific test than ASMA for diagnosing autoimmune liver disease, with about 52% to 85% of those affected having the anti-actin antibody.


How is it used?
The ASMA test is primarily ordered along with antinuclear antibodies (ANA) to help diagnose autoimmune hepatitis. Other autoantibodies, such as liver-kidney microsomal type 1 (LKM1) antibodies and antimitochondrial antibodies (AMA), may also be ordered to help diagnose autoimmune hepatitis and distinguish it from other causes of liver disease or injury.
The anti-actin test may be ordered as an initial screening test for autoimmune hepatitis instead of the ASMA test. If it is positive, it may be followed by the ASMA to confirm the finding.


When is it ordered?
This test and the ANA test are ordered when a doctor suspects that the patient has autoimmune hepatitis. They are usually ordered when a patient presents with symptoms such as fatigue and jaundice (yellowing of the skin and eyes) along with abnormal findings on liver tests (such as aspartate aminotransferase (AST) and/or bilirubin), results that may be found during routine blood tests.

ASMA and ANA are usually ordered following or sometimes with a variety of tests that are used to help diagnose and/or rule out other causes of liver injury. These causes can include infections (such as viral hepatitis), drugs, alcohol abuse, toxins, genetic conditions, metabolic conditions, and primary biliary cirrhosis.
An anti-actin test may be ordered instead of the ASMA when the doctor wants to screen for autoimmune hepatitis. This test is relatively new. In some cases, it is taking the place of the ASMA test; in others it may be followed by an ASMA for confirmation. The ultimate clinical utility of the anti-actin test has yet to be established.




What does the test result mean?
NOTE: A standard reference range is not available for this test. Because reference values are dependent on many factors, including patient age, gender, sample population, and test method, numeric test results have different meanings in different labs. Your lab report should include the specific reference range for your test. Lab Tests Online strongly recommends that you discuss your test results with your doctor. For more information on reference ranges, .


When significant amounts of ASMA and ANA are present in the blood, the most likely cause is autoimmune hepatitis. When both are present, then systemic lupus erythematosus can be essentially ruled out (ANA will be positive with lupus, but ASMA will not).
When anti-actin antibodies are present in significant quantities in a patient with clinical signs of autoimmune hepatitis, then it is likely that the patient has the condition. In most cases, if the anti-actin is positive, the ASMA will also be positive. Since actin is only one of several cytoskeleton proteins, it is possible for a person to have anti-smooth muscle antibodies even when the anti-actin test is negative.



Is there anything else I should know?
Concentrations of ASMA may be lower in children and in those with compromised immune systems, and levels may vary over the course of the disease. Up to 20% of patients with autoimmune hepatitis will not be positive for ASMA, ANA, or LKM1 antibodies.

Small amounts of ASMA may be present, along with AMA, in up to 50% of patients with primary biliary cirrhosis and may be found in other conditions such as infectious mononucleosis and some cancers. Anti-actin antibodies may be present in about 22% of patients with primary biliary cirrhosis
The presence of ASMA, anti-actin antibodies, and ANA are highly suggestive of autoimmune hepatitis but not diagnostic. When significant concentrations of both are present and the doctor suspects autoimmune hepatitis, then a liver biopsy may be performed to look for characteristic signs of damage and scarring in the liver tissue.





من مواضيع الريمـ في المنتدى


التعديل الأخير تم بواسطة الريمـ ; 08-19-2008 الساعة 04:36 AM
التوقيع

{حظ عـيني لو تـشوفك كل يوم...
.
.
   
رد مع اقتباس
 
 
 
 
قديم 08-21-2008, 06:12 PM   #3
نورا
بيوكيميائي برونزي
 
الصورة الرمزية نورا

 









نورا غير متواجد حالياً
افتراضي

السلام عليكم ورحمة الله وبركاته
شـكــ وبارك الله فيك ـــرا لك ... لك مني أجمل تحية . :newset (14)::newset (14):



من مواضيع نورا في المنتدى

   
رد مع اقتباس
 
 
إضافة رد


الذين يشاهدون محتوى الموضوع الآن : 1 ( الأعضاء 0 والزوار 1)
 
أدوات الموضوع
انواع عرض الموضوع

تعليمات المشاركة
لا تستطيع إضافة مواضيع جديدة
لا تستطيع الرد على المواضيع
لا تستطيع إرفاق ملفات
لا تستطيع تعديل مشاركاتك

BB code is متاحة
كود [IMG] متاحة
كود HTML معطلة

الانتقال السريع

المواضيع المتشابهه
الموضوع كاتب الموضوع المنتدى مشاركات آخر مشاركة
موسوعة قسم المختبر الاميرال ستالين تقنيات المعمل - Lab's techniques 34 01-26-2013 02:11 AM
45 فلاش من الفلاشات الكيميائية الرائعة vb2all الكيمـياء - Chemistry 1 11-24-2011 12:35 PM
تحليل السكر وكل ما يتعلق بـ "السكري" dato تقنيات المعمل - Lab's techniques 6 08-02-2008 11:00 PM
موسوعة قسم المختبر الاميرال ستالين المواضيع المميزة 1 02-05-2008 01:30 AM
تحليل السكر وكل ما يتعلق بـ "السكري" فارس البادية تقنيات المعمل - Lab's techniques 1 10-11-2007 03:02 AM



الساعة الآن 05:12 PM


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2021, vBulletin Solutions, Inc.
يوتك