ehab10f
01-17-2007, 06:23 AM
Classification of Hormones by Mechanism of Action.
Hormones that bind to intracellular receptors
Androgens
Calcitriol (1,25[OH]2-D3)
Estrogens
Glucocorticoids
Mineralocorticoids
Progestins
Retinoic acid
Thyroid hormones (T3 and T4)
II. Hormones that bind to cell surface receptors
A. The second messenger is cAMP
2-Adrenergic catecholamines
-Adrenergic catecholamines
Adrenocorticotropic hormone
Antidiuretic hormone
Calcitonin
Chorionic gonadotropin, human
Corticotropin-releasing hormone
Follicle-stimulating hormone
Glucagon
Lipotropin
Luteinizing hormone
Melanocyte-stimulating hormone
Parathyroid hormone
Somatostatin
Thyroid-stimulating hormone
B. The second messenger is cGMP
Atrial natriuretic factor
Nitric oxide
C. The second messenger is calcium or phosphatidylinositols (or both)
Acetylcholine (muscarinic)
1-Adrenergic catecholamines
Angiotensin II
Antidiuretic hormone (vasopressin)
Cholecystokinin
Gastrin
Gonadotropin-releasing hormone
Oxytocin
Platelet-derived growth factor
Substance P
Thyrotropin-releasing hormone
D. The second messenger is a kinase or phosphatase cascade
Adiponectin
Chorionic somatomammotropin
Epidermal growth factor
Erythropoietin
Fibroblast growth factor
Growth hormone
Insulin
Insulin-like growth factors I and II
Leptin
Nerve growth factor
Platelet-derived growth factor
Prolactin
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General Features of Hormone Classes
Group I Group II
Types Steroids, iodothyronines, calcitriol, retinoids Polypeptides, proteins,
glycoproteins, catecholamines
Solubility Lipophilic Hydrophilic
Transport proteins Yes No
Plasma half-life Long (hours to days) Short (minutes)
Receptor Intracellular Plasma membrane
Mediator Receptor-hormone complex cAMP, cGMP, Ca2+, metabolites of
complex phosphoinositols, kinase cascades
Hormones that bind to intracellular receptors
Androgens
Calcitriol (1,25[OH]2-D3)
Estrogens
Glucocorticoids
Mineralocorticoids
Progestins
Retinoic acid
Thyroid hormones (T3 and T4)
II. Hormones that bind to cell surface receptors
A. The second messenger is cAMP
2-Adrenergic catecholamines
-Adrenergic catecholamines
Adrenocorticotropic hormone
Antidiuretic hormone
Calcitonin
Chorionic gonadotropin, human
Corticotropin-releasing hormone
Follicle-stimulating hormone
Glucagon
Lipotropin
Luteinizing hormone
Melanocyte-stimulating hormone
Parathyroid hormone
Somatostatin
Thyroid-stimulating hormone
B. The second messenger is cGMP
Atrial natriuretic factor
Nitric oxide
C. The second messenger is calcium or phosphatidylinositols (or both)
Acetylcholine (muscarinic)
1-Adrenergic catecholamines
Angiotensin II
Antidiuretic hormone (vasopressin)
Cholecystokinin
Gastrin
Gonadotropin-releasing hormone
Oxytocin
Platelet-derived growth factor
Substance P
Thyrotropin-releasing hormone
D. The second messenger is a kinase or phosphatase cascade
Adiponectin
Chorionic somatomammotropin
Epidermal growth factor
Erythropoietin
Fibroblast growth factor
Growth hormone
Insulin
Insulin-like growth factors I and II
Leptin
Nerve growth factor
Platelet-derived growth factor
Prolactin
-------------------------------------------------------------------------------------------------------------
General Features of Hormone Classes
Group I Group II
Types Steroids, iodothyronines, calcitriol, retinoids Polypeptides, proteins,
glycoproteins, catecholamines
Solubility Lipophilic Hydrophilic
Transport proteins Yes No
Plasma half-life Long (hours to days) Short (minutes)
Receptor Intracellular Plasma membrane
Mediator Receptor-hormone complex cAMP, cGMP, Ca2+, metabolites of
complex phosphoinositols, kinase cascades